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hESCs and iPSCs

We have been using stem cell models and differentiation protocols for several years to model human cardiomyocytes, non myocytes and engineered heart tissue. This work is expanding and we have experts capable of deriving and utilizing patient derived human induced pluripotent stem cells as we move towards personalized medicine.

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We generate donor-derived induced pluripotent stem cells (iPSCs) to model cardiometabolic diseases and to study individuals on a dish. iPSCs are stem cells generated from a small amount of blood and can be differentiated into many different cell-types including cardiomyocytes (heart muscle cells), fibroblasts, smooth muscle cells, macrophages, et cetera. Through these differentiated cell-types, we study the mechanisms and pathophysiology of cardiometabolic diseases.

We generated research-grade iPSCs and quality-control them with a battery of gold-standard assays to evaluate their pluripotency, differentiation potential, and genomic stability.

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