Cardiac Epigenomics
and
Genetic Variation
Personalized Medicine
​The basic science of how gene regulation works keeps evolving as technologies sharpen. We adopt and exploit advances in technologies to push forward our understanding of regulation and heart biology and disease.
01
Epigenomics
​We found that as much as gene expression and epigenomic signals change in disease, they also vary from individual to individual.
02
Genetic Variants
Cardiac traits are influenced by genetic variants. Phenotypic refinement and collecting genetic diversity is helping us to learn more about human heart failure pathways. We are exploring south-east Asian genetic backgrounds which are understudied and susceptible to disease.
03
Massively Parralel Reporter Assays
​We are implementing and adopting MPRA technologies and machine learning to help identify regulatory genetic variants that influence individual risk of heart failure and targetable human genes.
04
Personalized Medicine
We believe that in the future medicine and clinical practice should be optimized for each patient.
