Matias I. Autio
I am a Senior Scientist based in the Genome Institute of Singapore. I hold a joint-appointment in the Foo-lab in NUS as a Senior Research Fellow. My research interests include the establishment and use of genomic safe harbours (GSH) for targeted transgene expression in human cells. GSH can be utilized in many applications related to gene and cell therapy as well as in basic research. Part of the GSH work has been published in a pre-print.
I routinely use many genome engineering tools, including CRISPR-Cas9 in many different flavours (from cutting Cas9 to prime-editing and anything in between) in the laboratory. With the different tools I generate cellular models of (heart) disease and development mainly utilizing hES and hiPS. In addition to the above, I am also developing tools for high and low throughput analysis and testing of regulatory elements.
Outside the lab my time is spent taking care of three young children.