Francesco Paolo Ruberto

Research Fellow

I am a molecular and cellular biologist who obtained a Ph.D. in cardiovascular science at the University of Lausanne Medical School, in Switzerland in the laboratory of Prof. Thierry Pedrazzini. My work particularly focused on the role of long noncoding RNAs (lncRNA) in cardiomyocyte proliferation. Applying a variety of techniques, I performed an extensive characterization of a novel lncRNA, implicated in cardiomyocyte metabolism and proliferation. Importantly, these results have therapeutic values for promoting regeneration in the diseased heart. The general understanding of lncRNAs is expanding and it is now knowledge that some lncRNAs can be translated into functional micropeptides, a new class of regulatory molecules mediators of essential biological processes. Recently, I joined the laboratory of Prof. Roger Foo, at the Department of Medicine at the National University of Singapore, where I am investigating the role of lncRNA derived micropeptides in metabolism and heart disease.