Research

The Foo Lab’s main interest is in the molecular mechanisms that regulate cardiac biology and disease; particularly genomic, transcriptomic and epigenomic patterns. Previously we have utilised single cell RNA-sequencing to identify cardiomyocyte subpopulations that transition to immature dedifferentiation like cell states during Heart Failure and to characterise novel deregulated RNAs such as circular or long non-coding RNAs.

Another key interest is understanding genetic variation that influences disease risk and biology particularly in relation to South East Asia. We have mapped out cardiac enhancer promoter maps and identified genetic variants that influence interindividual variation in cis regulatory activity.

We also spend time adopting, implementing and optimising new technologies which are fundamental to evolving our understanding of biology and disease. Recent examples including moving into spatial RNA-sequencing, developing RNA sensors and functional genomic screening with CRISPR based tools. Established technologies are heavily relied upon too including stem and induced pluripotent cells as well as primary cell isolation, in vivo surgical models and gene therapy approaches.

In addition to all things molecular and cardiac research, the Foo Lab is passionate and committed to training young scientists and clinicians, inspiring knowledge and challenging people. Last but not least, Foo Lab has also begun to participate in public health initiatives and outreach to promote a Heart Healthy Singapore. Stay-tuned for upcoming updates, publications and opportunities to work with us.