Publications

[vc_row][vc_column][trx_section animation=”zoomIn”][trx_title align=”left” bottom=”huge”]Publications[/trx_title][trx_accordion initial=”1″][trx_accordion_item title=”2022″][vc_column_text]

1. Hawe JS, Wilson R, Schmid KT, Zhou L, Lakshmanan LN, Lehne BC, Kühnel B, Scott WR, Wielscher M, Yew YW, Baumbach C, Lee DP, Marouli E, Bernard M, Pfeiffer L, Matías-García PR, Autio MI, Bourgeois S, Herder C, Karhunen V, Meitinger T, Prokisch H, Rathmann W, Roden M, Sebert S, Shin J, Strauch K, Zhang W, Tan WLW, Hauck SM, Merl-Pham J, Grallert H, Barbosa EGV; MuTHER Consortium, Illig T, Peters A, Paus T, Pausova Z, Deloukas P, Foo RSY, Jarvelin MR, Kooner JS, Loh M, Heinig M, Gieger C, Waldenberger M, Chambers JC. Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function. Nat Genet. 2022 Jan;54(1):18-29. doi: 10.1038/s41588-021-00969-x Epub 2022 Jan 3.
2. Y Zhu, M Ackers-Johnson, R Foo. T cells: a hidden corner to be explored for treating heart failure. Eur Heart J 2022 May 13;ehac241. doi: 1093/eurheartj/ehac241.
3. Chukwuemeka George Anene-Nzelu,  Peter Yiqing Li, Tuan Danh Anh Luu, Shi Ling Ng, Zenia Tiang, Bangfen Pan, Wilson Lek Wen Tan, Matthew Ackers-Johnson, Ching Kit Chen, Yee Phong Lim, Rina Wang Miao Qin, Wee Woon Chua, Lim Xin Yi, Roger Sik-Yin Foo and Yusaku Nakabeppu. 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction Oxid Med Cell Longev. 2022 Mar 27;2022:9180267. doi: 10.1155/2022/9180267. eCollection 2022.
4. Ng CH, Xiao J, Lim WH, Chin YH, Yong JN, Tan DJH, Tay P, Syn N, Foo R, Chan M, Chew N, Tan EX, Huang DQ, Dan YY, Tamaki N, Siddiqui MS, Sanyal AJ, Loomba R, Noureddin M, Muthiah MD. Placebo effect on progression and regression in NASH: Evidence from a meta-analysis. Hepatology. 2022 Jan 6. doi: 10.1002/hep.32315.
5. Yong JN, Ng CH, Lee CW, Chan YY, Tang ASP, Teng M, Tan DJH, Lim WH, Quek J, Xiao J, Chin YH, Foo R, Chan M, Lin W, Noureddin M, Siddiqui MS, Muthiah MD, Sanyal A, Chew NWS. Non-alcoholic fatty liver disease association with structural heart, systolic and diastolic dysfunction: a meta-analysis. Hepatol Int. 2022 Apr;16(2):269-281. doi: 10.1007/s12072-022-10319-6. Epub 2022 Mar 23.
6. Sazzad F, Hon JKF, Ramanathan K, Nah JH, Ong ZX, Ti LK, Foo R, Tay E, Kofidis T. Design variation, implantation and outcome of transcatheter mitral valve prosthesis: A comprehensive review. Front Cardiovasc Med. 2022 Feb 24;8:782278. doi: 10.3389/fcvm.2021.782278.
7. Tomar S, Klinzing DC, Kit CC, Gan LH, Moscarello T, Reuter C, Ashley EA, Foo R. Causative variants for inherited cardiac conditions in a Southeast Asian Population cohort. Circ Genom Precis Med. 2022 Feb 7:CIRCGEN121003536. doi: 10.1161/CIRCGEN.121.003536.
8. Nguyen V, Tu TM, Mamauag MJB, Lai J, Saffari SE, Aw TC, Ong L, Foo RSY, Chai SC, Fones S, Zhang M, Puar TH. Primary Aldosteronism More Prevalent in Patients With Cardioembolic Stroke and Atrial Fibrillation. Front Endocrinol (Lausanne). 2022 Apr 19;13:869980. doi: 10.3389/fendo.2022.869980. eCollection 2022.
9. Ng GY, Sheng DPLK, Bae HG, Kang SW, Fann DY, Park J, Kim J, Alli-Shaik A, Lee J, Kim E, Park S, Han JW, Karamyan V, Okun E, Dheen T, Hande MP, Vemuganti R, Mallilankaraman K, Lim LHK, Kennedy BK, Drummond GR, Sobey CG, Gunaratne J, Mattson MP, Foo RS, Jo DG, Arumugam TV. Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain. Geroscience. 2022 Mar 31. doi: 10.1007/s11357-022-00537-z. Online ahead of print.
10. Yeong T, Mai AS, Lim OZH, Ng CH, Chin YH, Tay P, Lin C, Muthiah M, Khoo CM, Dalakoti M, Loh PH, Chan M, Yeo TC, Foo R, Wong R, Chew NWS, Lin W. Can glucose-loweriung medications improve outcomes in non-diabetic heart failure patients? A Bayesian network meta-analysis. ESC Heart Fail. 2022 Apr;9(2):1338-1350. doi: 10.1002/ehf2.13822.
11. González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RS, Chan MYY, Aimo A, Anene-Nzelu GC, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Gal TB, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñez J, Piepoli MF, Rakisheva A, Ristic A, Rossignol P, Savarese G, Tocchetti CG, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJ, Bayes-Genis A. Cardiac remodelling Part 1: From cells and tissues to circulating biomarkers. Eur J Heart Fail. 2022 Mar 25. doi: 10.1002/ejhf.2493.
12. Zhai W, Lai H, Kaya NA, Chen J, Yang H, Lu B, Lim JQ, Ma S, Chew SC, Chua KP, Alvarez JJS, Chen PJ, Chang MM, Wu L, Goh BKP, Chung AY, Chan CY, Cheow PC, Lee SY, Kam JH, Kow AW, Ganpathi IS, Chanwat R, Thammasiri J, Yoong BK, Ong DB, de Villa VH, Dela Cruz RD, Loh TJ, Wan WK, Zeng Z, Skanderup AJ, Pang YH, Madhavan K, Lim TK, Bonney G, Leow WQ, Chew V, Dan YY, Tam WL, Toh HC, Foo RS, Chow PK. Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study. Natl Sci Rev. 2021 Oct 29;9(3):nwab192. doi: 10.1093/nsr/nwab192. eCollection 2022 Mar.
13. Kong G, Chew NWS, Ng CH, Chin YH, Lim OZH, Ambhore A, Ng G, Kong W, Poh KK, Foo R, Yip J, Yeo TC, Low AF, Lee CH, Chan MY, Tan HC, Loh PH. Prognostic Outcomes in Acute Myocardial Infarction Patients Without Standard Modifiable Risk Factors: A Multiethnic Study of 8,680 Asian Patients. Front Cardiovasc Med. 2022 Mar 29;9:869168. doi: 10.3389/fcvm.2022.869168. eCollection 2022.
14. Huang Z, Do DV, Beh D, Lee CK, Yan B, Foo R, Tambyah PA. Effects of severe acute respiratory syndrome coronavirus 2 infection on male hormona profile, ACE2 and TMPRSS2 expression, and potential for transmission of severe acute respiratory syndrome coronavirus 2 in semen of Asian men. F S Sci. 2022 Feb;3(1):29-34. doi: 10.1016/j.xfss.2021.11.003. Epub 2021 Nov 20.
15. Selvaraji S, Efthymios M, Foo RSY, Fann DY, Lai MKP, Chen CLH, Lim KL, Arumugam TV. Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia. Theranostics. 2022 Mar 21;12(7):3007-3023. doi: 10.7150/thno.71815. eCollection 2022.
16. Xia X, Toh DWK, Ng SL, Zharkova O, Poh KK, Foo RSY, Wang JW, Kim JE. Impact of following a healthy dietary pattern with co-consuming wolfberry on number and function of blood outgrowth endothelial cells from middle-aged and older adults. Food Funct. 2022 Jan 4;13(1):76-90. doi: 10.1039/d1fo02369a.

[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2021″][vc_column_text]

1. Zhou J, Azizan EAB, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Argentesi G, Cottrell E, Amar L, Wu X, O’Toole S, Goodchild E, Marker A, Senanayake R, Garg S, Åkerström T, Backman S, Jordan S, Polubothu S, Berney DM, Gluck A, Lines KE, Thakker RV, Tuthill A, Joyce C, Kaski JP, Karet Frankl FE, Metherell LA, Teo AED, Gurnell M, Parvanta L, Drake WM, Wozniak E, Klinzing D, Kuan JL, Tiang Z, Gomez Sanchez CE, Hellman P, Foo RSY, Mein CA, Kinsler VA, Björklund P, Storr HL, Zennaro MC, Brown MJ. Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause. Nat Genet. 2021 Aug 12. doi: 10.1038/s41588-021-00906-y.
2. Anene-Nzelu CG, Lee MCJ, Tan WLW, Dashi A, Foo RSY. Genomic enhancers in cardiac development and disease. Nat Rev Cardiol. 2021 Aug 11. doi: 10.1038/s41569-021-00597-2. 
3. Chai RJ, Werner H, Li PY, Lee YL, Nyein KT, Solovei I, Luu TDA, Sharma B, Navasankari R, Maric M, Sim LYE, Loh YJ, Aliwarga E, Cheong JWL, Chojnowski A, Autio MI, Haiyang Y, Boon Tan KK, Keng CT, Ng SL, Chew WL, Ferenczi M, Burke B, Foo RSY*, Stewart CL*. Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy. Nat Commun. 2021 Aug 5;12(1):4722. doi: 10.1038/s41467-021-24849-4.
4. Zeps N, Lysaght T, Chadwick R, Erler A, Foo R, Giordano S, San Lai P, Schaefer GO, Xafis V, Chew WL, Sugarman J. Ethics and regulatory considerations for the clinical translation of somatic cell human epigenetic editing. Stem Cell Reports. 2021 Jul 13;16(7):1652-1655. doi: 10.1016/j.stemcr.2021.06.004. Epub 2021 Jul 1.
5. Chan YHB, Loh LM, Foo RS, Loh WJ, Lim DST, Zhang M, Sultana R, Tan YK, Ng KS, Tay D, Swee DS, Au V, Tay TL, Khoo J, Zhu L, Lee L, Tan SY, Kek PC, Puar TH. Re-evaluating absent clinical success after adrenalectomy in unilateral primary aldosteronism. Surgery. 2021 Jun 25:S0039-6060(21)00500-6. doi: 10.1016/j.surg.2021.05.038.
6. Wu D, Li PY, Pan B, Tiang Z, Dou J, Williantarra I, Pribowo AY, Nurdiansyah R; SG Peranakan Project, Foo RSY*, Wang C*. Genetic admixture in the culturally unique Peranakan Chinese population in Southeast Asia. Mol Biol Evol. 2021 Jun 21:msab187. doi: 10.1093/molbev/msab187. 
7. Lim CK, Efthymios M, Tan W, Autio MI, Tiang Z, Li PY, Foo RSY. Dimethyl sulfoxide (DMSO) enhances direct cardiac reprogramming by inhibiting the bromodomain of coactivators CBP/P300. J Mol Cell Cardiol. 2021 Jun 16:S0022-2828(21)00130-9. doi: 10.1016/j.yjmcc.2021.06.008.
8. Webster G, Aburawi EH, Chaix MA, Chandler S, Foo R, Islam AKMM, Kammeraad JAE, Rioux JD, Al-Gazali L, Sayeed MZ, Xiao T, Zhang H, Xie L, Hou C, Ing A, Yap KL, Wilde AAM, Bhuiyan ZA. Life-threatening arrhythmias with autosomal recessive TECRL variants. Europace. 2021 May 21;23(5):781-788. doi: 10.1093/europace/euaa376.
9. Foo YY, Motakis E, Tiang Z, Shen S, Lai JKH, Chan WX, Wiputra H, Chen N, Chen CK, Winkler C, Foo RSY, Yap CH. Effects of extended pharmacological disruption of zebrafish embryonic heart biomechanical environment on cardiac function, morphology and gene expression. Dev Dyn. 2021. May 30. doi: 10.1002/dvdy.378.
10. Toh DWK, Xia X, Sutanto CN, Low JHM, Poh KK, Wang JW, Foo RS, Kim JE. Enhancing the cardiovascular protective effects of a healthy dietary pattern with wolfberry (Lycium barbarum): A randomised controlled trial. Am J Clin Nutr. 2021 May 8:nqab062. doi: 10.1093/ajcn/nqab062.
11. Sims CHC, Autio MI, Buskin A, Cheung C, Heer R, Foo RSY, Wang X. Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines. Stem Cell Res. 2021 Apr;52:102238. doi: 10.1016/j.scr.2021.102238. Epub 2021 Feb 11.
12. Madsen A, Krause J, Höppner G, Hirt MN, Tan WLW, Lim I, Hansen A, Nikolaev VO, Foo RSY, Eschenhagen T, Stenzig J. Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes. J Mol Cell Cardiol. 2021 May;154:115-123. doi: 10.1016/j.yjmcc.2021.02.002. Epub 2021 Feb 12.
13. McKimpson WM, Chen Y, Irving JA, Zheng M, Weinberger J, Tan WLW, Tiang Z, Jagger AM, Chua SC Jr, Pessin JE, Foo RS, Lomas DA, Kitsis RN. Conversion of the death inhibitor ARC to a killer activates pancreatic beta-cell death in diabetes. Dev Cell. 2021 Mar 22;56(6):747-760.e6. doi: 10.1016/j.devcel.2021.02.011. Epub 2021 Mar 4.

[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2020″][vc_column_text]

1. Zhu Y, Do VD, Richards AM, Foo R. What we know about cardiomyocyte dedifferentiation. J Mol Cell Cardiol. 2020 Dec 1;152:80-91. doi: 10.1016/j.yjmcc.2020.11.016.
2. Feng L, Romero-Garcia R, Suckling J, Tan J, Larbi A, Cheah I, Wong G, Tsakok M, Lanskey B, Lim D, Li J, Yang J, Goh B, Teck TGC, Ho A, Wang X, Yu JT, Zhang C, Tan C, Chua M, Li J, Totman JJ, Wong C, Loh M, Foo R, Tan CH, Goh LG, Mahendran R, Kennedy BK, Kua EH. Effects of choral singing versus health education on cognitive decline and aging: a randomized controlled trial. Aging (Albany NY). 2020 Dec 18;12. doi: 10.18632/aging.202374.
3. Sorokin V, Vickneson K, Kofidis T, Woo CC, Lin XY, Foo R, Shanahan CM. Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation. Front Immunol. 2020 Nov 26;11:599415. doi: 10.3389/fimmu.2020.599415.
4. Webster G, Aburawi EH, Chaix MA, Chandler S, Foo R, Islam AKMM, Kammeraad JAE, Rioux JD, Al-Gazali L, Sayeed MZ, Xiao T, Zhang H, Xie L, Hou C, Ing A, Yap KL, Wilde AAM, Bhuiyan ZA. Life-threatening arrhythmias with autosomal recessive TECRL variants. Europace. 2020 Dec 25:euaa376. doi: 10.1093/europace/euaa376.
5. Yu R, Sun Y, Ye KX, Feng Q, Lim SL, Mahendran R, Cheah IK, Foo RSY, Chua RY, Gwee X, Loh M, Sarmugam R, Khine WWT, Chao YX, Larbi A, Lee YK, Kumar AP, Kennedy BK, Kua EH, Feng L. Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore. Aging (Albany NY). 2020 Nov 18;12(23):23889-23899. doi: 10.18632/aging.104051.
6. Schaefer GO, Labude MK, Zhu Y, Foo RS, Xafis V. International Reporting Mechanism for Unethical Germline Gene Editing Experiments Is Needed. Trends Biotechnol. 2020 Nov 4:S0167-7799(20)30261-4. doi: 10.1016/j.tibtech.2020.10.001.
7. Karthikeyan G, Fung E, Foo RS. (2020) Alternative Hypothesis to Explain Disease Progression in Rheumatic Heart Disease. Circulation. 142(22):2091-2094. doi: 10.1161/CIRCULATIONAHA.120.050955. 
8. Robinson EL, Anene-Nzelu CG, Rosa-Garrido M, Foo RSY. (2020) Cardiac Cardiac epigenetics: Driving signals to the cardiac epigenome in development and disease. J Mol Cell Cardiol. 21;151:88. doi: 10.1016/j.yjmcc.2020.11.005. 
9. Schaefer GO, Labude MK, Zhu Y, Foo RS, Xafis V. International reporting mechanism for unethical germline gene editing experiments is needed. Trends Biotechnol. 2020 Nov 4:S0167-7799(20)30261-4. doi: 10.1016/j.tibtech.2020.10.001.
10. Puar TH, Loh LM, Loh WJ, Lim DST, Zhang M, Tan PT, Lee L, Swee DS, Khoo J, Tay D, Tan SY, Zhu L, Gani L, King TF, Kek PC, Foo RS. Outcomes in unilateral primary aldosteronism after surgical or medical therapy. Clin Endocrinol. 2020 Oct 15. doi: 10.1111/cen.14351.
11. Lu D, Chatterjee S, Xiao K, Riedel I, Wang Y, Foo R, Bär C, Thum T. (2020). MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes. J Mol Cell Cardiol, S0022-2828(20)30274-1. org/10.1016/j.yjmcc.2020.08.017
12. Chan MY, Efthymios M, Tan SH, Pickering JW, Troughton R, Pemberton C, Ho HH, Prabath JF, Drum CL, Ling LH, Soo WM, Chai SC, Fong A, Oon YY, Loh JP, Lee CH, Foo RSY, Ackers-Johnson MA, Pilbrow A, Richards AM. (2020). Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics. Circulation, 10.1161/CIRCULATIONAHA.119.045158. org/10.1161/CIRCULATIONAHA.119.045158
13. Madsen A, Höppner G, Krause J, Hirt MN, Laufer SD, Schweizer M, Tan WLW, Mosqueira D, Anene-Nzelu CG, Lim I, Foo RSY, Eschenhagen T, Stenzig J. (2020). An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility. Circulation, 10.1161/CIRCULATIONAHA.119.044444. org/10.1161/CIRCULATIONAHA.119.044444
14. Gurung R, Choong AM, Woo CC, Foo R, Sorokin V.(2020). Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm. (2020). Int J Mol Sci, 21(17), E6334. org/10.3390/ijms21176334
15. Pua CJ, Tham N, Chin CWL, Walsh R, Khor CC, Toepfer CN, Repetti GG, Garfinkel AC, Ewoldt JF, Cloonan P, Chen CS, Lim SQ, Cai J, Loo LY, Kong SC, Chiang CWK, Whiffin N, de Marvao A, Lio PM, Hii AA, Yang CX, Le TT, Bylstra Y, Lim WK, Teo JX, Padilha K, Silva GV, Pan B, Govind R, Buchan RJ, Barton PJR, Tan P, Foo R, Yip JWL, Wong RCC, Chan WX, Pereira AC, Tang HC, Jamuar SS, Ware JS, Seidman JG, Seidman CE, Cook SA.(2020). Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 that Are Common in Chinese Patients. (2020). Circ Genome Precis Med, 10.1161/CIRCGEN.119.002823. doi.org/10.1161/CIRCGEN.119.002823
16. Puar, T.H., Tan, C., Tong, A., Zhang, M., Khoo, C., Tan, W.J., Kek, P.C., Loh, L., Yee, S., Lee, D.H., Chuah, M., Reilhac, A., Totman, J., Robins, E., & Foo, R. (2020). OR34-01 11C Metomidate PET-CT Identifies More Unilateral Primary Aldosteronism Than Adrenal Vein Sampling. J Endocrine Soc, 4. Doi:10.1210/jendso/bvaa046.581
17. Tan WLW, Anene-Nzelu CG, Wong E, Lee CJM, Tan HS, Tang SJ, Perrin A, Wu KX, Zheng W, Ashburn RJ, Pan B, Lee MY, Autio MI, Morley MP, Tam WL, Cheung C, Margulies KB, Chen L, Cappola TP, Loh M, Chambers J, Prabhakar S, Foo RSY. (2020). Epigenomes of human hearts reveal new genetic variants relevant for cardiac disease and phenotype. Circ Res, 127(6), 761-777. doi:10.1161/CIRCRESAHA.120.317254
18. Stenzig, J., Löser, A., Krause, J., Hansen, A., Höppner, G., Foo, R., & Eschenhagen, T. (2020). DNA methyl transferase 3A loss in human engineered heart tissue induces distinct alterations of contractility. J Mol Cell Cardiol, 140, 29-30. doi:10.1016/j.yjmcc.2019.11.069
19. Wu Q, Wang J, Tan WLW, Jiang Y, Wang S, Li Q, Yu X, Tan J, Liu S, Zhang P, Tiang Z, Chen Z, Foo RS, Yang HT. (2020). Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis. Cell Death Dis, 11(5), 354-16. doi:10.1038/s41419-020-2508-y
20. Wang, Y., Foo, R., & Thum, T. (2020). Using “old” medications to fight new COVID-19: Re-purposing with a purpose. J Mol Cell Cardiol, 146, 41-42. doi:10.1016/j.yjmcc.2020.07.005
21. Foo, R., Wang, Y., Zimmermann, W., Backs, J., & Wang, D. W. (2020). Cardiovascular molecular mechanisms of disease with COVID-19. J Mol Cell Cardiol, 141, 107-107. doi:10.1016/j.yjmcc.2020.04.010
22. Puar TH, Loh WJ, Lim DS, Loh LM, Zhang M, Foo RS, Lee L, Swee DS, Khoo J, Tay D, Kam JW, Dekkers T, Velema M, Deinum J, Kek PC. (2020). Aldosterone-potassium ratio predicts primary aldosteronism subtype. J Hyperten, 38(7), 1375-1383. doi:10.1097/HJH.0000000000002348
23. Bhatia NS, Lim JY, Bonnard C, Kuan JL, Brett M, Wei H, Cham B, Chin H, Bosso-Lefevre C, Dharuman P, Escande-Beillard N, Devasia AG, Goh CYJ, Kam S, Liew WK, Liew WK, Lin G, Jain K, Ng AY, Subramanian D, Xie M, Tan YM, Tawari NR, Tiang Z, Ting TW, Tohari S, Tong CK, Lezhava A, Ng SB, Law HY, Venkatesh B, Tomar S, Sethi R, Tan G, Shanmugasundaram A, Goh DL, Lai PS, Lai A, Tan ES, Ng I, Reversades B, Tan EC, Foo R, Jamuar SS; SUREKids Working Group. Singapore undiagnosed disease program: Genomic analysis aids diagnosis and clinical management. Arch Dis Child, 2020 Aug 20:archdischild-2020-319180. doi:10.1136/archdischild-2020-319180
24. Anene-Nzelu CG, Tan WLW, Lee CJM, Wenhao Z, Perrin A, Dashi A, Tiang Z, Autio MI, Lim B, Wong E, Tan HS, Pan B, Morley MP, Margulies KB, Cappola TP, Foo RS. (2020). Assigning distal genomic enhancers to cardiac disease–causing genes. Circulation, 142(9), 910-912. doi:10.1161/CIRCULATIONAHA.120.046040
25. Xing M, Ooi WF, Tan J, Qamra A, Lee PH, Li Z, Xu C, Padmanabhan N, Lim JQ, Guo YA, Yao X, Amit M, Ng LM, Sheng T, Wang J, Huang KK, Anene-Nzelu CG, Ho SWT, Ray M, Ma L, Fazzi G, Lim KJ, Wijaya GC, Zhang S, Nandi T, Yan T, Chang MM, Das K, Isa ZFA, Wu J, Poon PSY, Lam YN, Lin JS, Tay ST, Lee MH, Tan ALK, Ong X, White K, Rozen SG, Beer M, Foo RSY, Grabsch HI, Skanderup AJ, Li S, Teh BT, Tan P. (2020). Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. J Clin Invest, 130(6), 3005-3020. doi:10.1172/JCI126726

25. Li S, Nguyen NUN, Xiao F, Menendez-Montes I, Nakada Y, Tan WLW, Anene-Nzelu CG, Foo RS, Thet S, Cardoso AC, Wang P, Elhelaly WM, Lam NT, Pereira AHM, Hill JA, Sadek HA. (2020). Mechanism of eccentric cardiomyocyte hypertrophy secondary to severe mitral regurgitation. Circulation, 141(22), 1787-1799. doi:10.1161/CIRCULATIONAHA.119.043939
26. Lavenniah, A., Luu, T. D. A., Li, Y. P., Lim, T. B., Jiang, J., Ackers-Johnson, M., & Foo, R. S. (2020). Engineered circular RNA sponges act as miRNA inhibitors to attenuate pressure overload-induced cardiac hypertrophy. Mol Therap, 28(6), 1506-1517. doi:10.1016/j.ymthe.2020.04.006
27. Nguyen NUN, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WLW, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA. (2020). A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. Nature, 582(7811), 271-276. doi:10.1038/s41586-020-2228-6
28. Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA. (2020). Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression. Nat Metab, 2(2), 167-178. doi:10.1038/s42255-020-0169-x

[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2019″][vc_column_text]

Aldosterone–potassium ratio predicts primary aldosteronism subtype. Puar TH, Loh WJ, Lim DS, Loh LM, Zhang M, Foo RS, Lee L, Swee DS, Khoo J, Tay D, Kam JW, Dekkers T, Velema M, Deinum J, Kek PC. J Hypertens. 2019 Dec 16. Pubmed.

Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore. Wu D, Dou J, Chai X, Bellis C, Wilm A, Shih CC, Soon WWJ, Bertin N, Lin CB, Khor CC, DeGiorgio M, Cheng S, Bao L, Karnani N, Hwang WYK, Davila S, Tan P, Shabbir A, Moh A, Tan EK, Foo JN, Goh LL, Leong KP, Foo RSY, Lam CSP, Richards AM, Cheng CY, Aung T, Wong TY, Ng HH; SG10K Consortium, Liu J, Wang C. Cell. 2019 Oct 17;179(3):736-749.e15. Pubmed.

Circles in the heart and cardiovascular system. Lim TB, Lavenniah A, Foo RS. Cardiovasc Res. 2019 Sep 25. Pubmed.

Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7and Ctgf. Tan CY, Wong JX, Chan PS, Tan H, Liao D, Chen W, Tan LW, Ackers-Johnson M, Wakimoto H, Seidman JG, Seidman CE, Lunde IG, Zhu F, Hu Q, Bian J, Wang JW, Foo RS, Jiang J. Circ Res. 2019 Oct 11;125(9):834-846. Pubmed.

Genetic Mosaicism in Calmodulinopathy. Wren LM, Jiménez-Jáimez J, Al-Ghamdi S, Al-Aama JY, Bdeir A, Al-Hassnan ZN, Kuan JL, Foo RS, Potet F, Johnson CN, Aziz MC, Carvill GL, Kaski JP, Crotti L, Perin F, Monserrat L, Burridge PW, Schwartz PJ, Chazin WJ, Bhuiyan ZA, George AL Jr. Circ Genom Precis Med. 2019 Sep;12(9):375-385. Pubmed.

Upregulation of Yy1 Suppresses Dilated Cardiomyopathy caused by Ttn insufficiency. Liao D, Chen W, Tan CY, Wong JX, Chan PS, Tan LW, Foo R, Jiang J. Sci Rep. 2019 Nov 8;9(1):16330. Pubmed.

Dissecting chromatin architecture for novel cardiovascular targets.  Foo R, Anene-Nzelu CG, Rosa-Garrido M, Vondriska T. Circulation. 2019. Aug 6;140(6):446-448. Pubmed.

Aortic and pulmonary artery dilatation in Cantu syndrome: expanding the phenotype. Chew YR, Lim JY, Teoh OH, Chen CK, Foo R, Lai AH, Jamuar SS. Clin Dysmorphol. 2019 Jul;28(3):167-169. Pubmed.

Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy. Lim B, Aliwarga E, Luu T, Li P, Ng SL, Annadoray L, Sian S, Ackers-Johnson MA, Foo R. Cardiovasc Res. 2019 Dec 1;115(14):1998-2007. Pubmed.

Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic fatty liver disease. Kim H, Worlsey O, Yang E, Purbojati RW, Liang AL, Tan W, Moses DIDm Hartono S, Fan Vm Lim TKH, Schuster SC, Foo RS*, Chow PKH*, Pettersen S*.  Cell Mol Life Sci. 2019 May 22. Pubmed.

Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis. Arcinas C, Tan W, Fang W, Desai T, The D, Degirmenci U, Xu D, Foo R*, Lei S*. Nat Metab. link.

Langendorff-Free Isolation and Propagation of Adult Mouse Cardiomyocytes. Ackers-Johnson M, Foo RS. Methods Mol Biol. 2019;1940:193-204. Pubmed.

Toll-like Receptor 7 Deficiency Promotes Survival and Reduces Adverse Left Ventricular Remodeling After Myocardial Infarction. de Kleijn DPV, Chong SY, Wang X, Yatim SMJM, Fairhurst AM, Vernooij F, Zharkova O, Chan M, Foo RSY, Timmers L, Lam CSP, Wang JW. Cardiovasc Res 2019 Mar 4. Pubmed.

Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress-Gene Response. Lee DP, Tan WLW, Anene-Nzelu CG, Lee CJM, Li PY, Luu TDA, Chan CX, Tiang Z, Ng SL, Huang X, Efthymios M, Autio MI, Jiang J, Fullwood MJ, Prabhakar S, Lieberman Aiden E, Foo RS. Circulation. 2019 Apr 16;139(16):1937-1956. Pubmed.

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence. Xu W, Monaco G, Wong EH, Tan WLW, Kared H, Simoni Y, Tan SW, How WZY, Tan CTY, Lee BTK, Carbajo D, K G S, Low ICH, Mok EWH, Foo S, Lum J, Tey HL, Tan WP, Poidinger M, Newell E, Ng TP, Foo R, Akbar AN, Fülöp T, Larbi A. EBioMedicine. 2019 Jan;39:44-58. Pubmed.

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[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2017″][vc_column_text]

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo. See K, Tan WLW, Lim EH, Tiang Z, Lee LT, Li PYQ, Luu TDA, Ackers-Johnson M, Foo RS. Nat Commun. 2017 Aug 9;8(1):225. Pubmed.

Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived Xenografts. Mohamed Suhaimi NA, Phyo WM, Yap HY, Choy SHY, Wei X, Choudhury Y, Tan WJ, Tan LAPY, Foo RSY, Tan SHS, Tiang Z, Wong CF, Koh PK, Tan MH. Mol Cancer Ther. 2017 Sep;16(9):2035-2044. Pubmed.

Exclusion of alternative exon 33 of Ca_V1.2 calcium channels in heart is proarrhythmogenic. Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu Z, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S, Soong TW. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295. Pubmed.

Single-cell genomic profiling of acute myeloid leukemia for clinical use: A pilot study. Yan B, Hu Y, Ban KHK, Tiang Z, Ng C, Lee J, Tan W, Chiu L, Tan TW, Seah E, Ng CH, Chng WJ, Foo R. Oncol Lett. 2017 Mar;13(3):1625-1630. Pubmed.

Mutation in δ-Sg Gene in Familial Dilated Cardiomyopathy. Asadi M, Foo R, Salehi AR, Salehi R, Samienasab MR. Adv Biomed Res. 2017 Mar 7;6:32. Pubmed.

The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma. Zhai W, Lim TK, Zhang T, Phang ST, Tiang Z, Guan P, Ng MH, Lim JQ, Yao F, Li Z, Ng PY, Yan J, Goh BK, Chung AY, Choo SP, Khor CC, Soon WW, Sung KW, Foo RS, Chow PK. Nat Commun. 2017 Feb 27;8:4565. Pubmed.

A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 Mar 1;113(3):298-309. Pubmed.

Acute lymphoblastic leukemia in a child with a de novo germline gnb1 mutation. Brett M, Lai AH, Ting TW, Tan AM, Foo R, Jamuar S, Tan EC. Am J Med Genet A. 2017 Feb;173(2):550-552. Pubmed.

[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2016″][vc_column_text]A genomic and epigenomic comparison of fetal and adult human cardiac fibroblasts reveal novel key transcription factors in adult cardiac fibroblasts. M Jonsson, R Hartman, M Ackers-Johnson, W Tan, B Lim, T A B van Veen, R S Foo.  J Am Coll Card Basic Transl Sci. J2016 Nov 30;1(7):590-602. Pubmed.

The International Human Epigenome Consortium: A blueprint for scientific collaboration and discovery. Hendrik G Stennenberg, The International Human Epigenome Consortium, Martin Hirst. Cell. 2018 Nov 17;167(5):1145-1149. PubMed

Preparing health systems in Southeast and East Asia for new paradigms of care / personalised medicine in cancer: are healthy systems ready for evolving cancer management? J Lim, M Zafra, J Mocanu, G de Lima Lopes, R Foo, I Umareddy, A Jha, L Hickinbotham.  J Asian Publ Policy. July 2016. Link

ARCN1 mutations cause a recognizable craniofacial syndrome due to COPI-mediated transport defects. Izumi K, Brett M, Nishi E, Foo R, Passemard S, Tan E-C, El Ghouzzi V, Shirahige K. Am J Hum Genet. 2016. Aug 4;99(2):451-9. PubMed

AAV9 delivery of shRNA to the mouse heart. H Wakimoto, JG Seidman, RS Foo, J Jiang. Curr Protoc Mol Biol. 2016 Jul 1;115:23.16.1-9. PubMed

T-cell receptor αβ and CD19 depleted haploidentical stem cell transplant with reduced intensity conditioning for Hoyeraal-Hreidarsson syndrome with RTEL1 mutation. R Bhattacharyya, AM Tan, MY Chan, R Foo, S Jamuar, R Iyer. Bone Marrow Transplant. 2016 May;51:753-754. PubMed

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Non-Myocytes from the Adult Mouse Heart. Matthew Ackers-Johnson, Peter Y Li, Andrew P Holmes, Sian-Marie O’Brien, Davor Pavlovic and Roger S Foo. Circ Res. 2016 Sep 30;119(8):909-20. PubMed

Incidentalome from Genomic Sequencing: A Barrier to Personalized Medicine?Jamuar SS, Kuan JL, Brett M, Tiang Z, Wilson TLW, Lim YL, Liew KML, Javed A, Liew WK, Law HY, Tan ES, Lai A, Ng I, Teo YY, Venkatest B, Reversade B, Tan EC, Foo RS.  EBioMedicine. 2016 Feb 4;5:211-6. PubMed

Genetic analysis of cardiac SCN5A Gene in Iranian patients with hereditary cardiac arrhythmias. Asadi M, Foo R, Bhuiyan ZA, Samienasab MR, Salehi AR, Shahrzad S, Salehi R. Anatol J Cardiol. 2016 Mar;16(3):170-4. Pubmed.

Genetic analysis of Iranian family with hereditary cardiac arrhythmias by next generation sequencing. Asadi M, Foo R, Samienasab MR, Salehi AR, Kheirollahi M, Khanahmad H, Salehi R. Adv Biomed Res. 2016 Mar 16;5:55. Pubmed.

[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2015″][vc_column_text]A. Vujic, E. Robinson, S. Haider, M. Movassagh, A. Ferguson-Smith, R.S. Foo. Experimental heart failure modeled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B. J Mol Cell Cardiol. 2015 Mar 14;82:174-83. PubMed

Rachmin I, Foo RS, Razin E. Erbin, et al. FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy. Int J Cardiol. 2015 May 20;195:85-94. PubMed

Chong JH, Jamuar SS, Ong C, Thoon KC, Tan ES, Lai A, Aan MK, Wilson TLW, Foo R, Tan EC, Lau YL, Liew WK. Tricho-hepato-enteric syndrome (THE-S): two cases and review of the literature. Eur J Pediatr. 2015 May 15;174(10):1405-11. PubMed

Wong LL, Wee AS, Lim JY, Ng JY, Chong JP, Liew OW, Lilyanna S, Martinez EC, Ackers-Johnson MA, Vardy LA, Armugam A, Jeyaseelan K, Ng TP, Lam CS, Foo RS, Richards AM, Chen YT. Natriuretic peptide receptor 3 (NPR3) is regulated by microRNA-100. J Mol Cell Cardiol. 2015 May;82:13-21. PubMed

Lim JH, Ravikumar S, Wang YM, Thamboo TP, Ong L, Chen J, Goh JG, Tay SH, Chengchen L, Win MS, Leong W, Lau T, Foo R, Mirza H, Tan KS, Sethi S, Khoo AL, Chng WJ, Osato M, Netea MG, Wang Y, Chai LY. Bimodal Influence of Vitamin D in Host Response to Systemic Candida Infection-Vitamin D Dose Matters. J Infect Dis. 2015 Aug 15;212(4):635-44. PubMed[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2014″ id=”sc_accordion_item_1455014145897_2″][vc_column_text]Pilbrow AP, Cordeddu L, Cameron VA, Frampton CM, Troughton RW, Doughty RN, Whalley GA, Ellis CJ, Yandle TG, Richards AM, Foo RS. Circulating miR-323-3p and miR-652: Candidate markers for the presence and progression of acute coronary syndromes. Int J Cardiol. 2014 Sep 20;176(2):375-85. PubMed

Rachmin I, Foo RS, Razin E. Erbin, et al. Erbin is a negative modulator of cardiac hypertrophy. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5902-7. PubMed[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2012″ id=”sc_accordion_item_1455014172433_10″][vc_column_text]Gaspar-Pereira S, Foo RS, Oakley F, et al. The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. Am J Pathol. 2012 Mar;180(3):929-39. PubMed

Fernandez-Twinn DS, Foo R, Ozanne SE. The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation. Endocrinology. 2012 Dec;153(12):5961-71. PubMed

S. Haider, L. Cordeddu, A. Vujic, L. Siggens, R.S. Foo. Landscape of repetitive element methylation in human heart failure. Genome Biology. 2012 Oct 3;13(10):R90. PubMed

L. Siggens, N. Figg, M. Bennett, R.S. Foo. Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1. FASEB J. 2012 May;26(5):2117-24. PubMed[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2011″ id=”sc_accordion_item_1455014192185_3″][vc_column_text]M. Movassagh, M-K. Choy, D Knowles, L. Siggens, A. Vujic, T. Down, M. Goddard, M. Bennett, R.S. Foo. Distinct epigenomic features in human end-stage failing human hearts. 2011. Circulation. 2011 Nov 29;124(22):2411-22. PubMed

M-K. Choy, M. Movassagh, R.S. Foo. The human variome: genomic and epigenomic diversity. EMBO Mol Med. 2011 Oct;3(10):573-4. PubMed

M. Movassagh, A. Vujic, R.S. Foo. The 5th nucleotide: DNA methylation and heart failure. Epigenomics. 2011 Feb 3(1): 103-9. PubMed[/vc_column_text][/trx_accordion_item][trx_accordion_item title=”2010″ id=”sc_accordion_item_1455014216009_4″][vc_column_text]M-K. Choy, M. Movassagh, H-G. Goh, M.R. Bennett, T.A. Down, R.S. Foo. Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated. BMC Genomics. 2010 Sep 27;11(1):519. PubMed

R.S. Foo. Basic mechanisms in apoptosis and heart failure. Heart Metab. 2010. PubMed

M-K. Choy, M. Mossavagh, M. Goddard, A.M. Sanchez, N.D. Perkins, N. Figg, M.R. Bennett, J.S. Carroll, R.S. Foo. p53 piggy-backs onto NF-κB to regulate microRNA-21 expression. Genome Med. 2010 Jun 14;2(6):37. PubMed

M-K. Choy, M. Mossavagh, J.P. de Bono, K.M. Channon, M.R.Bennett, R.S. Foo. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. J Cell Physiol. 2010 Mar;222(3):635-9. PubMed

M. Movassagh, T.A. Down, M-K. Choy, M. Goddard, M.R. Bennett, R.S. Foo. Differential methylation correlates with differential expression of angiogenic factors in human heart failure. PLoS One. 2010 Jan 13;5(1):e8564. PubMed[/vc_column_text][/trx_accordion_item][/trx_accordion][/trx_section][/vc_column][/vc_row][vc_row][vc_column][vc_tta_accordion][vc_tta_section title=”Section 1″ tab_id=”1653435027878-c607540e-0c5a”][/vc_tta_section][vc_tta_section title=”Section 2″ tab_id=”1653435028029-6d0e5b25-6ae2″][/vc_tta_section][/vc_tta_accordion][/vc_column][/vc_row][vc_row][vc_column][vc_tta_accordion][vc_tta_section title=”Section 1″ tab_id=”1653435048841-64fea11a-bdf0″][/vc_tta_section][vc_tta_section title=”Section 2″ tab_id=”1653435048986-f73636ac-381d”][/vc_tta_section][/vc_tta_accordion][/vc_column][/vc_row]